Ca2+/H+ exchange

Contributor: Saverio Marchi
{"name":"Ca2+\/H+ exchange","theorem":{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"Ca2+","position":4},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":1}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"Ca2+","position":1},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":4}]}},"steps":[{"head":{"_type":"interaction","position":0,"components":[{"_type":"molecule","name":"Ca2+","position":1},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":4}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"Ca2+","position":1},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":4}]}},{"head":{"_type":"interaction","position":0,"components":[{"_type":"molecule","name":"Ca2+","position":4},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":1}]},"body":{"_type":"interaction","position":0,"components":[{"_type":"molecule","name":"Ca2+","position":1},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":4}]}},{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"Ca2+","position":4},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":1}]},"body":{"_type":"interaction","position":0,"components":[{"_type":"molecule","name":"Ca2+","position":4},{"_type":"protein","name":"LETM1","position":2},{"_type":"molecule","name":"H+","position":1}]}}]}

Theorem

Information

The Leucine zipper-EF-hand-containing transmembrane protein1 (LETM1), located at the inner mitochondrial membrane, has been indicated to fuction as the Ca2+/H+ antiporter, by exchanging two protons from the intermembrane space for a divalent calcium ion from the matrix. It has also been proposed that LETM1 might assemble as an hexamer.

 

References:

Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science. 2009 Oct 2;326(5949):144-7. doi: 10.1126/science.1175145. PMID: 19797662.

Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2249-54. doi: 10.1073/pnas.1308558110. Epub 2013 May 28. PMID: 23716663.

Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X, Cong Y, Shen Y. Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a
Ca2+/H+ antiporter. Sci Rep. 2016 Sep 27;6:34174. doi: 10.1038/srep34174. PMID: 2766990.

 

Link to other Databases:

Reactome: https://reactome.org/content/detail/R-HSA-8949687

Mitochondrial processes

Demonstrative and biological steps

Dynamic view

Mito-location

Not Available/Not Relevant
    M
    Matrix
      IM
      Inner Membrane
        IMS
        Inter-Membrane Space
          OM
          Outer Membrane
            PMS
            Peri-Mitochondrial Space

              Dynamic mito-location